The twelfth season of MADtv was broadcast from September 16, 2006, to May 19, 2007, with 22 episodes.
12 - 1Episode #1201 Sep. 16, 2006- 12 - 2Howie Mandel, Chingy Sep. 23, 2006
- 12 - 3Episode #1203 Sep. 30, 2006
- 12 - 5Episode #1205 Nov. 11, 2006
- 12 - 6Episode #1206 Nov. 18, 2006
- 12 - 7Episode #1207 Nov. 25, 2006
- 12 - 8Rocky Balboa, Mr. T Dec. 09, 2006
- 12 - 9Jeff Probst Dec. 16, 2006
- 12 - 10Episode #1210 Jan. 06, 2007
- 12 - 11Episode #1211 Jan. 20, 2007
- 12 - 12Mary Lynn Rajskub Feb. 03, 2007
- 12 - 13Episode #1213 Feb. 10, 2007
- 12 - 14Lise Nova, Gwen Stefani Feb. 17, 2007
- 12 - 15Episode #1215 Feb. 24, 2007
- 12 - 16Rob Corddry Mar. 10, 2007
- 12 - 17Edge Mar. 17, 2007
- 12 - 18Tom Bergeron Apr. 07, 2007
- 12 - 19Jamie Kennedy Apr. 14, 2007
- 12 - 20Leah Remini Apr. 21, 2007
- 12 - 21Carl Edwards May. 05, 2007
- 12 - 22Fred Willard May. 19, 2007
